Endocrine Abstracts

Background: Continuous subcutaneous insulin infusion (CSII) is proving superior in reducing HbA1c compared to multiple daily injections (MDI) in both the adult and paediatric populations. This study aims to compare the two methods, and evaluate the importance of education when starting insulin pump therapy in children.Design: Patients who attended a ‘pump school’ provided by the Royal Manchester Children’s Hospital between January 2010 and...

Despite the recognized importance of thyroid hormones (TH) for normal brain development, little is known about the critical molecular events underlying this role. We investigated the molecular basis of TH action on the developing brain by: (1) comparing genome-wide gene expression patterns in the cerebellum of euthyroid, hypothyroid and hyperthyroid juvenile mice treated with 6-propyl thiouracil or mercapto-methylimidazole /perchlorate using DNA microarrays; and (2) investigat...